Data tillgängliga från svenska myndigheter och stora offentliga dataproducenter
- SciLifeLab Autoimmunity and Serology profiling facility, statistik för SARS-CoV-2 antikroppstest: Uppdateras manuellt.
Data tillgängliga från svenska forskargrupper
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Senast uppdaterad: 2021-09-24
|Projekt||Senast uppdaterad||Tillgängliga data|
Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2
Roxhed N, Bendes A, Dale M, Mattsson C, Hanke L, [...], Schwenk JM
Nat Commun 12 (1)
Seropositivity in blood donors and pregnant women during 9-months of SARS-CoV-2 transmission in Stockholm, Sweden
Dopico XC, Muschiol S, Christian M, Hanke L, Sheward DJ, [...], Karlsson Hedestam GB
Rudberg A, Havervall S, Månberg A, Jernbom Falk A, Aguilera K, [...], Thålin C
Nat Commun 11 (1) 5064
SARS-CoV-2 may pose an occupational health risk to healthcare workers. Here, we report the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms and occupational exposure to SARS-CoV-2 among healthcare workers at a large acute care hospital in Sweden. The seroprevalence of IgG antibodies against SARS-CoV-2 was 19.1% among the 2149 healthcare workers recruited between April 14th and May 8th 2020, which was higher than the reported regional seroprevalence during the same time period. Symptoms associated with seroprevalence were anosmia (odds ratio (OR) 28.4, 95% CI 20.6-39.5) and ageusia (OR 19.2, 95% CI 14.3-26.1). Seroprevalence was also associated with patient contact (OR 2.9, 95% CI 1.9-4.5) and covid-19 patient contact (OR 3.3, 95% CI 2.2-5.3). These findings imply an occupational risk for SARS-CoV-2 infection among healthcare workers. Continued measures are warranted to assure healthcare workers safety and reduce transmission from healthcare workers to patients and to the community.
|2020-10-08||Data available upon request and collaboration inquiries welcome.|
Development, clinical translation, and utility of a COVID-19 antibody test with qualitative and quantitative readouts.
Bortz RH, Florez C, Laudermilch E, Wirchnianski AS, Lasso G, [...], Chandran K
mSphere 6 (2)
The COVID-19 global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to place an immense burden on societies and healthcare systems. A key component of COVID-19 control efforts is serologic testing to determine the community prevalence of SARS-CoV-2 exposure and quantify individual immune responses to prior infection or vaccination. Here, we describe a laboratory-developed antibody test that uses readily available research-grade reagents to detect SARS-CoV-2 exposure in patient blood samples with high sensitivity and specificity. We further show that this test affords the estimation of viral spike-specific IgG titers from a single sample measurement, thereby providing a simple and scalable method to measure the strength of an individual's immune response. The accuracy, adaptability, and cost-effectiveness of this test makes it an excellent option for clinical deployment in the ongoing COVID-19 pandemic.
|2020-09-11||Available on request|
Hultström M, Persson B, Eriksson O, Lipcsey M, Frithiof R, [...], Nilsson B
Crit Care 24 (1) 496
No abstract available
|2020-08-12||Available on request|
Lindahl JF, Hoffman T, Esmaeilzadeh M, Olsen B, Winter R, [...], Lundkvist Å
Infect Ecol Epidemiol 10 (1) 1789036
The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 created severe logistic problems. Some elderly care homes therefore started to screen their personnel to secure the safety of the elderly and to avoid unnecessary quarantine of potentially immune employees. Secondary data from a screening with a COVID-19 rapid test for detection of SARS-CoV-2-specific IgM and IgG of 1,005 employees in 22 elderly care homes in Stockholm, Sweden, were analyzed. Seropositive employees were found in 21 out of the 22 care homes. In total, 23% (231/1,005) of the employees tested positive for antibodies against SARS-CoV-2, and 14.3% (144/1,005) were found positive for IgM (either alone or combined with IgG), indicating recent or present infection. Of those that tested seropositive, 46.5% did not report any clinical symptoms, indicating pre- or asymptomatic infections. Reported symptoms with the highest correlation with seropositivity were fever and loss of smell and taste. These results suggest that antibody testing of employees in elderly care homes is valuable for surveillance of disease development and a crucial screening tool in the effort to decrease the death toll in this pandemic.
|2020-08-05||Serological responses of 1,005 employees to SARS-CoV-2 at 22 different elderly care homes in Stockholm|