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Data i fokus

“Data i fokus” notiserna visar nyligen publicerade dataset rörande COVID-19 och SARS-CoV-2 av forskare affilierade till ett svenskt lärosäte. Målet är att lyfta fram öppen forskning, öppna data och att möjliggöra återanvändning av forskningsdata i framtida forskning. Om du har publicerat data som du skulle vilja visa upp i datanotiserna, skicka ett förslag till oss.

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Reliable profiling of IgG and IgM levels in home-sampled dried blood spots
Reliable profiling of IgG and IgM levels in home-sampled dried blood spots

2021-10-18

Roxhed et al. demonstrate how self sampling at home can be effective by profiling IgG and IgM levels against several versions of SARS-CoV-2 proteins (S, RBD, N) in home-sampled dried blood spots. Metadata records and the analysis scripts used for the article are shared.
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Metabolic perturbation of SARS-CoV-2 as a potential future therapeutic target
Metabolic perturbation of SARS-CoV-2 as a potential future therapeutic target

2021-10-07

Krishnan et al. showed that the SARS-CoV-2 virus can use and rewire metabolic pathways to their benefit in replication. Their findings indicate that host metabolic perturbation could be an attractive strategy to limit replication. Code and data from the study have been shared pubicly.
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Statistics, information, and research about Post COVID-19 condition in Sweden now available on the Portal
Statistics, information, and research about Post COVID-19 condition in Sweden now available on the Portal

2021-09-06

Today, for the first time, the Portal provides information and summary statistics to show the impact of ‘Post COVID-19 condition’ (‘Postcovid’ in Swedish) in Sweden, and the research underway. All data and code used on the page is publicly available.
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Human genetic mapping can provide insight about COVID-19 pathogenesis and drug development
Human genetic mapping can provide insight about COVID-19 pathogenesis and drug development

2021-08-10

Researchers in the COVID-19 Host Genetics initiative performed genome-wide association meta-analyses to examine the loci involved in the variation of COVID-19 disease severity and susceptibility between individuals. The data and code used in the project have been made available.
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New phenomics method for antiviral drug discovery may help to fight COVID-19
New phenomics method for antiviral drug discovery may help to fight COVID-19

2021-08-02

Rietdijk and colleagues used a new phenomics approach to aid in the discovery of both novel drugs and drugs that could potentially be repurposed to fight COVID-19. Both data and code are published.
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Interferon signatures in SARS-CoV-2 infected liver cells could provide knowledge for new antiviral therapies
Interferon signatures in SARS-CoV-2 infected liver cells could provide knowledge for new antiviral therapies

2021-07-06

Chen and Saccon et al. used a proteomics-based approach to study how SARS-CoV-2 infection affected Type-1 interferon signalling in liver cells. Both data and code are published.
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Cost-effective COVseq method could be used for large-scale genomic surveillance of VOCs
Cost-effective COVseq method could be used for large-scale genomic surveillance of VOCs

2021-07-01

Simonetti, Zhang, and Harbers et al. have shared a cost-effective, scalable and versatile method (alongside associated data and code) that could facilitate large-scale genomic surveillance of variants of concern (VOCs).
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The Swedish SARS-CoV-2 and COVID-19 research output since the beginning of the pandemic
The Swedish SARS-CoV-2 and COVID-19 research output since the beginning of the pandemic

2021-06-21

To date, 1.400+ journal articles and preprints have been published by researchers affiliated to a Swedish university or research institute. The database of these publications is compiled by the Portal and is available for download.
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The Swedish COVID-19 Data Portal one year on - focus on openly sharing data and code
The Swedish COVID-19 Data Portal one year on - focus on openly sharing data and code

2021-06-03

One year ago today, on June 3rd 2020, the Swedish COVID-19 Data Portal was launched and became the first national node of the European data sharing platform for COVID-19 research efforts. Here, we look back at the highlights over the last year.
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Quantitative proteomic provides important knowledge about cellular response against SARS CoV-2
Quantitative proteomic provides important knowledge about cellular response against SARS CoV-2

2021-05-19

Saccon and colleagues studied changes in protein abundance caused by SARS-CoV-2 virus in susceptible cell lines using quantitative proteomics. All proteomics were made data openly available in different repositories.
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Proteomic profiling in COVID-19 patients as biomarkers to monitor disease severity
Proteomic profiling in COVID-19 patients as biomarkers to monitor disease severity

2021-04-13

Recent study examined a large number of inflammatory, immune response, cardiovascular, and neurological markers in the blood of patients variously impacted by COVID-19. Data and analysis code were shared in public repositories.
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Swedish COVID-19 symptom data contribute to accelerating research about pandemic
Swedish COVID-19 symptom data contribute to accelerating research about pandemic

2021-03-29

COVID Symptom Study Sweden collects data through a smartphone app to investigate prevalence, risk factors, and symptoms associated with COVID-19. To date, over 200.000 volunteers have enrolled in the study.
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SARS-CoV-2 wastewater data from cities across Sweden now available
SARS-CoV-2 wastewater data from cities across Sweden now available

2021-03-16

The Swedish COVID-19 Data Portal is launching a section with wastewater epidemiology data. Weekly data from Uppsala, Stockholm, Umeå, and Örebro is presented in graphs and available for download.
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Neanderthal gene protecting against severe COVID-19 could be potential new drug target
Neanderthal gene protecting against severe COVID-19 could be potential new drug target

2021-03-10

A new study largely relying on existing data re-use identified circulating proteins influencing COVID-19 susceptibility and severity. Based on these results, work on repurposing relevant existing drugs work can now be launched.
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Database of COVID-19 sample collections and biobanks in Sweden launched
Database of COVID-19 sample collections and biobanks in Sweden launched

2021-02-24

In collaboration with Biobank Sweden, today we are launching a new section of the portal: the Swedish COVID-19 Sample Collection Database. The database allows to search for available biobank sample collections.
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Bevacizumab treatment beneficial for patients with severe COVID-19
Bevacizumab treatment beneficial for patients with severe COVID-19

2021-02-18

A recently published clinical study investigating bevacizumab, a humanized anti-VEGF monoclonal antibody, offers promising results in fighting severe COVID-19. Treatment progress data and analysis code were shared publicly.
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Nanobodies promising new therapeutics for treatment of SARS CoV-2
Nanobodies promising new therapeutics for treatment of SARS CoV-2

2021-02-16

A recently published study characterizes the mechanisms by which nanobodies neutralize or prevent of infection in molecular detail. Crystallographic coordinates, cryo-EM density maps, and atomic coordinates were deposited to public databases.
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Data on COVID-19 testing in Uppsala County and dashboard with maps, trends and more now available
Data on COVID-19 testing in Uppsala County and dashboard with maps, trends and more now available

2021-02-11

The data portal is now launching a page with the CRUSH Covid dashboard with an option to download data on COVID-19 testing in each postal code of Uppsala County.
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Mechanism of entry used by human species D adenoviruses proving important for COVID-19 vaccine development
Mechanism of entry used by human species D adenoviruses proving important for COVID-19 vaccine development

2021-01-18

New study identifies a noncanonical entry mechanism used by human adenoviruses, important for development of adenovirus-based vaccine vectors. The reported X-ray structural data was made available through the Protein Data Bank.
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A novel approach to discover and characterize broad-spectrum antivirals
A novel approach to discover and characterize broad-spectrum antivirals

2020-12-18

Newly discovered antiviral compounds showed broad-range antiviral activity against pathogenic RNA viruses such as SARS-CoV-2. The authors share data freely in open repositories.
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Pathogenesis of hyperinflammatory syndrome associated with COVID-19 in children
Pathogenesis of hyperinflammatory syndrome associated with COVID-19 in children

2020-12-07

Multiple autoantibodies and specific cytokines could be involved in the pathogenesis of MIS-C associated with COVID-19. Data and code made available in open repositories.
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An alpaca-derived nanobody can potently neutralize SARS-CoV-2
An alpaca-derived nanobody can potently neutralize SARS-CoV-2

2020-11-27

Leo Hanke and colleagues identified a SARS-CoV-2 RBD-specific single domain antibody fragment, Ty1, that potently neutralizes the virus. Ty1 should now be further investigated as a candidate for antiviral therapy.
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Synthetic nanobodies are easy to produce and can effectively neutralize SARS-CoV-2
Synthetic nanobodies are easy to produce and can effectively neutralize SARS-CoV-2

2020-11-24

Recently published study demonstrates that it is possible to select highly specific binders with neutralizing activity against SARS-CoV-2 from a synthetic nanobody library in a short timeframe.
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MAIT cell activation and dynamics studied in relation to COVID-19 disease severity
MAIT cell activation and dynamics studied in relation to COVID-19 disease severity

2020-11-18

Tiphaine Parrot and colleagues studied changes in conventional and unconventional T cell subsets in patients with various disease severity using flow cytometry. The results were published along with the data.
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Crystal structure of SARS CoV-2 nsp-10 - a potential drug target for COVID-19
Crystal structure of SARS CoV-2 nsp-10 - a potential drug target for COVID-19

2020-11-03

A study by Rogstam and colleagues published along with the crystal structure of SARS CoV-2 non-structural protein 10 in the Protein Data Bank provides a starting point for structure-guided drug discovery and design.
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Bayesian model for estimating the impact of mobility patterns on COVID-19 infection
Bayesian model for estimating the impact of mobility patterns on COVID-19 infection

2020-10-23

Patrick Bryant and Arne Elofsson shared code and instructions for modelling COVID-19 development using MCMC simulations based on mobile phone mobility data from Google mobility reports.
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Nu publiceras den första studien baserad på data från storskalig serologisk analys vid SciLifeLab
Nu publiceras den första studien baserad på data från storskalig serologisk analys vid SciLifeLab

2020-10-15

Studien utgår endast från en bråkdel av den mängd SARS-CoV-2-data som samlats in av ScilifeLab Autoimmunity and Serology profiling facility.
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Neandertalgenom kopplas till ökad risk för svår COVID-19 infektion i studie som använder datadriven forskningsmetod
Neandertalgenom kopplas till ökad risk för svår COVID-19 infektion i studie som använder datadriven forskningsmetod

2020-10-02

Studie av Hugo Zeberg and Svante Pääbo som är helt baserad på öppen data publiceras med fri tillgång i Nature.
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Studie av covid-19 RT-PCR test som inte kräver RNA-extraktion publicerad med data
Studie av covid-19 RT-PCR test som inte kräver RNA-extraktion publicerad med data

2020-10-01

Data från artiklen är fritt tillgänglig via Nature Communications och kod finns på Github.
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Ny sida med statistik över SARS-CoV-2-antikroppstester som utförts av SciLifeLab
Ny sida med statistik över SARS-CoV-2-antikroppstester som utförts av SciLifeLab

2020-09-30

Nu lanserar vi en ny sida med grafer som visar statistik över de SARS-CoV-2-antikroppstester som utförts vid SciLifeLab Autoimmunity and Serology profiling facility.
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